Andras M. Komaromy, PhD, DVM
- Faculty, Training Faculty, Cellular & Molecular
Associate Professor, Small Animal Clinical Sciences
Ph.D., 2002, University of Florida
D.V.M., 1993, University of Zurich
My laboratory studies the cellular and molecular disease mechanisms of inherited retinal and optic nerve diseases. We take advantage of unique large animal models in order to facilitate the transition of new findings from the laboratory bench towards clinical trials in human patients. Regardless of the underlying cause, the loss of cone photoreceptors most severely affects a person’s daily visual performance when affected by an inherited retinal disease such as retinitis pigmentosa (RP) or age-related macular degeneration (AMD). Our group studies achromatopsia, an inherited disease that primarily affects cones, as a model disorder. We have provided proof of principle that viral-mediated gene replacement therapy rescues cone function in canine models of achromatopsia. Another interest of ours is the study of primary open-angle glaucoma (POAG), a disease that affects the inner retina and optic nerve. It is one of the leading causes for blindness, but the precise disease mechanisms are poorly understood. We have developed a valuable model to further investigate the disease mechanisms in POAG, and we are developing new therapeutic strategies.