John L. Goudreau, DO, PhD
- Faculty, Training Faculty, Cellular & Molecular
Associate Professor, Pharmacology & Toxicology, Neurology & Ophthalmology
PhD., 1994, Michigan State University
D.O., 1995, Michigan State University
My research interests are focused on genetic and environmental factors involved in the pathogenesis of neurodegenerative disorders such as Parkinson's Disease (PD). PD is a progressive illness characterized by resting tremor, slowness and stiffness of movement in addition to problems with balance and walking. PD is a common disease, affecting nearly 1 million people in the United States. The cause of PD is unknown, but combinations of both genetic and environmental factors are thought to play an important role.
The work in my laboratory involves using rodent models to identify and characterize genetic and environmental factors that may lead to PD. Selective neurotoxin exposure, alone or in combination with transgenic or knockout animals are used to test the importance of environmental and genetic factors. Animals will be evaluated on the basis of their motor behavior in combination with neurochemical, pathological, and immunohistochemical changes in selected regions of the brain. In addition, genome-wide mRNA expression profiling is used to identify changes in expected and novel gene expression. Novel potential candidate genes will be screened for disease-prodisposing polymorphisms in patients with PD.