Stacie L. Demel, DO, PhD
- Faculty, Behavioral & Systems, Cellular & Molecular
Assistant Professor, Neurology and Ophthalmology
Ph.D., 2008, Michigan State University
D.O., 2010, Michigan State University
Stroke is the 5th leading cause of death in the US, but is the 3rd leading cause of death in women. We are interested in understanding the biological differences between men and women with special interest in the risks for development and treatment of intracranial aneurysms (IA). If ruptured, IAs cause a devastating type of stroke (subarachnoid hemorrhage) that often affects a younger population. Women are more likely to suffer from ruptured cerebral aneurysms, as are smokers and people with hypertension. Understanding who should be screened and which aneurysms should be treated (i.e.those more likely to rupture) to lower the incidence of subarachnoid hemorrhage is one of the major focuses of the lab.
To better understand cerebrovascular disease, we are using molecular biology techniques to measure changes in RNA levels and protein expression in rodent models of cerebrovascular disease. We will also study the functional changes to the neurovascular unit in rodent models of cerebrovascular disease using pressure arterial myography. Using this technique we can learn about functional changes to the blood vessel wall in a number of cerebrovascular diseases including but not limited to mechanical changes in the wall of aneurysms, in small vessel ischemic disease, CNS vasculopathy and vasospasm.
This is a new lab at MSU and a very exciting time for me. I completed the DO, PhD Program at MSU in the Department of Neuroscience in 2008 where I studied changes to the pre-junctional alpha2 adrenergic receptor and purinergic neurotransmission in hypertensive rats under the direction of Dr. Galligan. I am looking forward to exploring these new avenues of research that have piqued my interest over the last several years of clinical training. Please feel free to contact me with any questions.