Susan M. Barman, PhD
- Faculty, Behavioral & Systems
Professor, Pharmacology & Toxicology
Ph.D., 1976, Loyola University Medical Center
There is considerable data supporting the view that disturbances in control of autonomic nerve activity can contribute to the development or maintenance of hypertension, cardiac dysrhythmias, and other cardiovascular diseases. Our recent work demonstrates that neurons in a part of the medullary reticular formation called the lateral tegmental field (LTF) plays an important role in mediating autonomic reflexes. The reflexes that we study are important in various physiological and pathophysiological states. The major objectives of the neurophysiological research in my laboratory are:
1. to determine the types of excitatory and inhibitory neurotransmitters within the LTF that account for reflex-induced changes in sympathetic activity,
2. to identify the types of LTF neurons (sympathoexcitatory, sympathoinhibitory) that are responsible for reflex-induced changes in sympathetic activity,
3. to determine thye role of the LTF in control of phrenic nerve activity, controlling respiration.
In conjunction with the use of standard extracellular recording procedures, microiontophoresis, and microinjection techniques, this research relies heavily on state-of-the-art computer-aided analyses in both the time-domain (correlation analysis, spike-triggered averaging) and frequency-domain (power density spectra, coherence functions).
Please feel free to contact me if you have any questions about my research