Marie A. Doyle

Faculty Advisor:  Michelle S. Mazei-Robison, PhD
B.S., 2012, Carnegie Mellon University
Entered Program in 2015
 doylema8@msu.edu

Academic and Research Background

I graduated from Carnegie Mellon University in 2012 with a B.S. in Biological Sciences. During my time at Carnegie Mellon, I interned at Merck & Co. in the lab of Dr. Lili Zhang and explored tau hyperphosphorylation in the rTg4510 mouse model of Alzheimer's Disease. After graduation and a brief career as an IT consultant, I returned to research and joined the lab of Dr. Eric Nestler at the Mount Sinai School of Medicine, which studies the epigenetic regulation of genes involved in addiction and depression. I enrolled as a Ph.D. student in the Neuroscience Program at Michigan State University in 2015. My current work in the Mazei-Robison lab focuses on how drugs of abuse alter serum-and glucocorticoid-regulated kinase 1 (SGK1) signaling in the VTA.

Publications

  • Feng J, Peña CJ, Purushothaman I, Engmann O, Walker D, Issler O, Brown A, Doyle M, Harrigan E, Mouzon EA, Vialou V, Shen L, Dawlaty MM, Jaenisch R, Nestler EJ (2017). Tet1 in nucleus accumbens opposes depression- and anxiety-like behaviors. Neuropsychopharmacology. DOI: 10.1038/npp.2017.6
  • Bagot RC, Cates HM, Purushothaman I, Lorsch ZS, Walker DM, Wang J, Huang X, Schlüter OM, Maze I, Peña CJ, Heller EA, Issler O, Wang M, Song W, Stein JL, Liu X, Doyle MA, Scobie KN, Sun H, Neve RL, Geschwind D, Dong Y, Shen L, Zhang B, Nestler EJ (2016). Circuit-wide transcriptional profiling reveals brain region-specific gene networks regulating depression susceptibility. Neuron. DOI: 10.1016/j.neuron.2016.04.015
  • Khibnik LA, Beaumont M, Doyle M, Heshmati M, Slesinger PA, Nestler EJ, Russo SJ (2015). Stress and cocaine trigger divergent and cell type-specific regulation of synaptic transmission at single spines in nucleus accumbens. Biological Psychiatry (In Press). DOI: 10.1016/j.biopsych.2015.05.022

Posters and Presentations

  • Doyle MA, Bali V, Kaska S, Cooper SE, Mazei-Robison MS (2017). Changes in ventral tegmental area serum- and glucocorticoid-inducible kinase 1 (SGK1) catalytic activity and phosphorylation alter drug-related behaviors. Society for Neuroscience (Washington, DC).
  • Bali V, Doyle MA, Cooper SE, Kaska S, Mazei-Robison MS (2017). Determination of the upstream kinases responsible for increased phosphorylation of serum and glucocorticoid-inducible kinase by drugs of abuse. Society for Neuroscience (Washington, DC).
  • Doyle MA, Bali V, Kaska S, Cooper SE, Mazei-Robison MS (2017). Changes in ventral tegmental area serum- and glucocorticoid-inducible kinase 1 (SGK1) catalytic activity and phosphorylation alter drug-related behaviors. Experimental Biology (Chicago, IL). The FASEB Journal, April 2017 31:985.11
  • Doyle MA, Bali V, Kaska S, Cooper SE, Mazei-Robison MS (2016). Role of ventral tegmental area SGK1 phosphorylation and activity in drug-associated behaviors. American College of Neuropsychopharmacology (Hollywood, FL), Neuropsychopharmacology. DIO: 10.1038/npp.2016.242
  • Doyle MA, Bali V, Kaska S, Cooper SE, Mazei-Robison MS (2016). Drugs of abuse alter SGK1 phosphorylation and activity in the ventral tegmental area. Society for Neuroscience (San Diego, CA).
  • Walker DM, Doyle MA, Bagot RC, Burek D, Harrigan EJ, Hodes GE, Rabkin J, Calipari ES, Cates HM, Issler O, Cahill ME, Labonte B, Heller EA, Feng J, Pena CJ, Ribeiro E, Engmann O, Lorsch Z, Hamilton PJ, Nestler EJ (2015). Paternal transmission of stress -induced phenotypes are transmitted via male germ cells. Society for Neuroscience (Chicago, IL).
  • Walker DM, Juarez B, Calipari ES, Doyle MA, Cates HM, Hodes GE, Crumiller M, Kennedy PJ, Han MH, Nestler EJ (2015). Adolescent social stress results in sex-specific effects on cocaine elicited and anxiety-like behaviors in the adult mouse. Society for Behavioral Neuroendocrinology (Pacific Grove, CA).
  • Walker DM, Doyle MA, Harrigan EJ, Cates HM, Hodes GE, Kennedy PJ, Ferguson D, Labonte B, Sun H, Rabkin J, Nestler EJ (2014). Adolescent social stress induces sex-specific effects on cocaine-elicited and anxiety-like behaviors in adult mouse. Society for Neuroscience (Washington, D.C.).
  • Doyle MA, Terracina G, Zhang L (2011). Age-dependent tau phosphorylation in the Tg4510 mouse model of Alzheimer's Disease. Merck & Co. Summer Research Fair (Kenilworth, NJ).