Neurological effects of Fragile X Syndrome, regulation and modulation of neuronal excitability of thalamocortical circuits and interactions between basal ganglia and thalamic circuits.
Assistant Professor, Department of Pediatrics and Human Development; College of Human Medicine
Grand Rapids Campus
4012 Grand Rapids Research Center; 400 Monroe Ave NW; Grand Rapids, MI 49503
Cerebral cortex development: (e.g., neural development of sensory systems)
Neurophysiology and neuroplasticity within thalamocortical circuits. Neurophysiological alterations associated with Developmental disorders (fragile X syndrome, Autism), Epilepsy, and Parkinson's Disesase
Developmental exposure to drugs of abuse, development of the dopamine system, etiology and experimental therapeutics of Parkinson's disease
Development of neuroprotective pharmacological agents and strategies for the treatment of dopamine neurodegenerative disorders including Parkinson's Disease and Restless Legs Syndrome (RLS)
Neuromodulation, Neuroimaging of cortical function, Post-injury plasticity, Somatosensory system, Traumatic brain injury, Peripheral nerve injury, molecular probes, Optical imaging, Development of molecular-based neuromodulation technologies
Regenerate and redefine the interface between neurons and electrodes implanted in the brain, improving the understanding and control of device-tissue integration
Primary neuronal cultures, ex vivo and in vivo gene therapy, stereotaxic surgery, immunohistochemistry, neuro substructure microdissections, behavioral evaluations of motor performance, microscopy, long term deep brain stimulation platform
Structure-function relation of retinal ganglion cells undergoing glaucoma-related degeneration in the primate eye. Development of treatment strategies aimed at mitigating or preventing glaucomatous retinal ganglion cell degeneration
Magnetic Resonance Imaging (MRI) technique development. Use neuroimaging to understand mild traumatic brain injury, normal aging, Alzheimer's disease (AD), AD risk reduction, and effects of hypertension on the brain.