Ke Dong, PhD
- East Lansing, Faculty, Training Faculty, Cellular & Molecular
Ph.D., 1993, Cornell University
East Lansing Campus
The research in Dong lab centers on the molecular biology, neurophysiology and neurotoxicology of voltage-gated ion channels in insects and arachnids. Currently, we focus on two types of ion channels: sodium channels and a new cation channel, known as DSC1 in Drosophila. Major research directions are: 1) to elucidate the molecular mechanisms of action and resistance of sodium channel-targeting insecticides including pyrethroid insecticides; and 2) to investigate the role of the DSC1 family of cation channels in neurophysiology, neurotoxicology and behavior. Drosophila melanogaster and various arthropod pests and disease vectors including Aedes and Anopheles mosquitoes are used as experimental models. Both in vitro and in vivo functional analysis systems, such as Xenopus oocyte expression system and single sensillum recording, are employed in our studies. Please visit our lab website for project details.
Neurological effects of Fragile X Syndrome, regulation and modulation of neuronal excitability of thalamocortical circuits and interactions between basal ganglia and thalamic circuits.
Assistant Professor, Department of Pediatrics and Human Development; College of Human Medicine
Grand Rapids Campus
4012 Grand Rapids Research Center; 400 Monroe Ave NW; Grand Rapids, MI 49503
Cerebral cortex development: (e.g., neural development of sensory systems)
Neurophysiology and neuroplasticity within thalamocortical circuits. Neurophysiological alterations associated with Developmental disorders (fragile X syndrome, Autism), Epilepsy, and Parkinson's Disesase
Assistant Professor, Physiology
Neurobiology of Chronic Pain
Developmental exposure to drugs of abuse, development of the dopamine system, etiology and experimental therapeutics of Parkinson's disease
Development of neuroprotective pharmacological agents and strategies for the treatment of dopamine neurodegenerative disorders including Parkinson's Disease and Restless Legs Syndrome (RLS)
Neuromodulation, Neuroimaging of cortical function, Post-injury plasticity, Somatosensory system, Traumatic brain injury, Peripheral nerve injury, molecular probes, Optical imaging, Development of molecular-based neuromodulation technologies
Regenerate and redefine the interface between neurons and electrodes implanted in the brain, improving the understanding and control of device-tissue integration
Primary neuronal cultures, ex vivo and in vivo gene therapy, stereotaxic surgery, immunohistochemistry, neuro substructure microdissections, behavioral evaluations of motor performance, microscopy, long term deep brain stimulation platform
Structure-function relation of retinal ganglion cells undergoing glaucoma-related degeneration in the primate eye. Development of treatment strategies aimed at mitigating or preventing glaucomatous retinal ganglion cell degeneration
Magnetic Resonance Imaging (MRI) technique development. Use neuroimaging to understand mild traumatic brain injury, normal aging, Alzheimer's disease (AD), AD risk reduction, and effects of hypertension on the brain.