Nicholas M. Kanaan, PhD

  • Grand Rapids, Faculty, Training Faculty, Cellular & Molecular

Associate Professor, Translational Neuroscience

Ph.D., 2007, Rush University Medical Center

Pub Med Search for Dr. Kanaan

Grand Rapids Campus

 Grand Rapids Research Center
 616-234-0956
 nicholas.kanaan@hc.msu.edu

Kanaan Lab Website
Translational Neuroscience Directory

Research Interests

Dr. Kanaan's laboratory researches neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) as well as the role of aging-related changes in neurodegenerative disease. Studies in the Kanaan lab focus on the mechanisms underlying degenerative diseases and exploring therapeutic strategies. A combination of experimental approaches, including in vitro and in vivo model systems, is used to tackle scientific questions.

One of the current topics under investigation is the role of tau, a microtubule-associated protein, in the pathogenesis of AD and other tauopathies. Tau has historically been described as a microtubule stabilizing protein; however, accumulating evidence supports a more diverse functional repertoire. In particular, his lab is interested in understanding how disease-related alterations in tau cause neuronal dysfunction through the disruption of axonal transport. A recently identified phosphatase-activating domain (PAD) in the extreme N-terminus of tau (amino acids 2-18) inhibits anterograde fast axonal transport through a signaling cascade involving the activation of protein phosphatase 1 and gylcogen synthase kinase 3. Using a multifaceted approach, he studies the molecular mechanisms behind tau-mediated axonal transport inhibition by expressing tau proteins in cultured neurons and neurons in vivo. To complement the studies in culture and animal models they use a host of in vitro biochemical and molecular biology assays.

Regardless of his specific basic science endeavors, one of Dr. Kanaan's fundamental aims is to conduct research that will ultimately translate into improvements in the lives of the people affected by these devastating diseases.

Melissa J. Allman, PhD

Assistant Professor, Psychology
East Lansing Campus
 206 Giltner Hall
 517-432-8779
 mjallman@msu.edu

Timing and time perception in autism

Amy A. Arguello, PhD

Assistant Professor, Psychology
East Lansing Campus
 213A Giltner Hall
 arguell5@msu.edu

Neural circuits and reconsolidation mechanisms contributing to drug relapse

William D. Atchison, PhD

Professor, Pharmacology & Toxicology
East Lansing Campus
 B331 Life Science
 517-353-4947
 atchiso1@msu.edu

Neurotransmitter release and synaptic transmission; models of human neuromuscular disorders of peripheral and central neurotransmission, chemical neurotoxicity, ion channel pharmacology

Susan M. Barman, PhD

Professor, Pharmacology & Toxicology
East Lansing Campus
 B426 Life Science
 517-432-3154
 barman@msu.edu

Central neural control of the cardiovascular system; sympathetic rhythms

Joseph A. Beatty, PhD

Assistant Professor, Physiology
East Lansing Campus
 2193 Biomedical and Physical Sciences
 517-884-5046
 beattyj7@msu.edu

Neurological effects of Fragile X Syndrome, regulation and modulation of neuronal excitability of thalamocortical circuits and interactions between basal ganglia and thalamic circuits.

Andrew R. Bender, PhD

Assistant Professor, Epidemiology and Biostatistics
Assistant Professor, Neurology and Ophthalmology
East Lansing Campus
 637 West Fee Hall
 517-884-7606
 bender@epi.msu.edu

Cognitive neuroscience of aging and lifespan development.

Alison I. Bernstein, PhD

Assistant Professor, Translational Neuroscience
Grand Rapids Campus
 Grand Rapids Research Center
 616-234-0957
 alison.bernstein@hc.msu.edu

Epigenetics in Parkinson's disease; toxicological models of Parkinson's disease

Andrea C. Bozoki, MD

Associate Professor, Neurology & Ophthalmology
East Lansing Campus
 A217 Clinical Center
 517-884-2482
 bozoki@msu.edu

Effects of aging and dementia on the memory networks of the brain, using functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI)

Jan W. Brascamp, PhD

Assistant Professor, Psychology
East Lansing Campus
 282A Psychology
 517-355-9562
 brascamp@msu.edu

The human visual system

S. Marc Breedlove, PhD

Barnett Rosenberg Professor of Neuroscience
Professor, Integrative Biology, Psychology
East Lansing Campus
 240 Giltner Hall
 517-355-1749
 breedsm@msu.edu

Effects of steroids on and the activation of plasticity in the human nervous system

Laura Y. Cabrera, PhD

Assistant Professor, Center for Ethics and Humanities in the Life Sciences, Translational Neuroscience
East Lansing Campus
 C211 East Fee
 517-355-7553
 laura.cabrera@ht.msu.edu

Ethical and societal implications of neurotechnology and advances in neuroscience

Daniel B. Campbell, Ph.D

Assistant Professor, Department of Pediatrics and Human Development; College of Human Medicine
Grand Rapids Campus
 Grand Rapids Research Center
 616-234-2839
 Daniel.Campbell@hc.msu.edu

Cerebral cortex development: (e.g., neural development of sensory systems)

Peter J. R. Cobbett, PhD

Associate Professor, Pharmacology & Toxicology
East Lansing Campus
 B446 Life Science
 517-353-5479
 cobbett@msu.edu

Ion channels and neuromuscular physiology of human and veterinary parasites

Timothy J. Collier, PhD

Professor, Translational Neuroscience
Grand Rapids Campus
 Grand Rapids Research Center
 (616)234-0953
 collie69@msu.edu

Models of Parkinson's disease to study mechanisms of degeneration and therapeutics; neurobiology of aging

Scott E. Counts, PhD

Associate Professor, Translational Neuroscience
Grand Rapids Campus
 Grand Rapids Research Center
 616-234-0997
 scott.counts@hc.msu.edu

Molecular pathogenic mechanisms of selective neuronal vulnerability in AD

C. Lee Cox, PhD

Chair, Physiology
Professor, Physiology
East Lansing Campus
 2201E Biomedical and Physical Sciences
 517-884-5060
 coxclee@msu.edu

Neurophysiology and neuroplasticity within thalamocortical circuits. Neurophysiological alterations associated with Developmental disorders (fragile X syndrome, Autism), Epilepsy, and Parkinson's Disesase

Shane R. Crandall, PhD

Assistant Professor, Physiology
East Lansing Campus
 2168 Biomedical and Physical Sciences
 517-884-5055
 cranda86@msu.edu

Structure and function of neural circuits in the mammalian brain; Basic physiology of neurons and synapses; Physiology of sensory systems; Optogenetics

Ke Dong, PhD

Professor, Entomology
East Lansing Campus
 438 Giltner Hall
 517-432-2034
 dongk@msu.edu

Insect voltage-gated ion channels, interaction between ion channels and insecticides and other neurotoxins, and molecular mechanisms of insecticide resistance

Heather L. Eisthen, PhD

Professor, Integrative Biology
East Lansing Campus
 342 Natural Science
 517-353-1953
 eisthen@msu.edu

Neuroethology, comparative and developmental vertebrate neurobiology

Kimberly M. Fenn, PhD

Associate Professor, Psychology
East Lansing Campus
 289B Psychology
 517-432-6258
 kfenn@msu.edu

Acquisition and consolidation of complex skills and episodic memory

James J. Galligan, PhD

Neuroscience Program Director
Professor, Pharmacology and Toxicology

East Lansing Campus
 108 Giltner Hall
 517-353-4776
 galliga1@msu.edu

Neurophysiology and pharmacology of autonomic nerves

Kathleen A. Gallo, PhD

Professor, Physiology
East Lansing Campus
 4180 Biomedical and Physical Sciences
 517-884-5156
 gallok@msu.edu

Protein kinase signaling in neurogenerative diseases

Julia Ganz, PhD

Assistant Professor, Integrative Biology
East Lansing Campus
 39 Giltner Hall
 ganz@msu.edu

Development and regeneration of the enteric nervous system; Endothelin signaling in neural crest development

Marcia N. Gordon, PhD

Professor, Translational Neuroscience
Grand Rapids Campus
 Grand Rapids Research Center
 616-234-2837
 Marcia.Gordon@hc.msu.edu

Innate immunity in neurodegerative diseases

John L. Goudreau, DO, PhD

Associate Professor, Pharmacology & Toxicology, Neurology & Ophthalmology
East Lansing Campus
 B436 Life Sciences
 517-884-2484
 john.goudreau@ht.msu.edu

Genetic and Environmental Factors in the Pathogenesis of Parkinson's Disease

Brian D. Gulbransen, PhD

MSU Foundation Professor
Associate Professor, Neuroscience & Physiology

East Lansing Campus
 3081 Biomedical and Physical Sciences
 517-884-5121
 gulbrans@msu.edu

Role of glia in neuroinflammation in the intestine

Colleen C. Hegg, PhD

Associate Professor, Pharmacology & Toxicology
East Lansing Campus
 B439B Life Science
 517-432-2339
 hegg@msu.edu

Mechanisms of neuroregeneration, environmental toxicants and damage to the olfactory system

Casey L. Henley, PhD

Director of Online Programs
Assistant Professor, Neuroscience Program

East Lansing Campus
 207 Giltner Hall
 517-884-9526
 mcgove14@msu.edu

Hanne M. Hoffmann, PhD

Assistant Professor, Animal Science
East Lansing Campus
 1230H Anthony Hall
 517-353-1415
 hanne@msu.edu

Behavioral neuroendocrinology and reproduction

Jie Huang, PhD

Professor, Radiology
East Lansing Campus
 164 Radiology
 517-884-3246
 jie@rad.msu.edu

Functional magnetic resonance imaging (fMRI) based systems level neuroscience research and its clinical application in migraine study

Alex W. Johnson, PhD

Associate Professor, Psychology
East Lansing Campus
 205 Giltner Hall
 517-432-8446
 awj@msu.edu

Neuronal mechanisms of learning and motivation

Cynthia L. Jordan, PhD

Professor, Neuroscience Program
East Lansing Campus
 239 Giltner Hall
 517-355-1722
 jordancy@msu.edu

Neurobiological mechanisms of sex differences in neurodegenerative/neuromuscular disease and mental disorders including anxiety and PTSD

Florian A. Kagerer, PhD

Associate Professor, Kinesiology
East Lansing Campus
 27Q IM Sports Circle
 517-432-9907
 fkagerer@msu.edu

Adaptive sensorimotor control in humans.

Nicholas M. Kanaan, PhD

Associate Professor, Translational Neuroscience
Grand Rapids Campus
 Grand Rapids Research Center
 616-234-0956
 nicholas.kanaan@hc.msu.edu

Molecular mechanisms underlying neurodegenerative diseases and developing novel therapeutic strategies that target disease mechanisms

David I. Kaufman, DO

Chair, Neurology & Ophthalmology
Medical Director, Sparrow Hospital Neurosciences
East Lansing Campus
 A217 Clincal Center
 517-432-9277
 kaufman1@msu.edu

Diagnosis, prognosis and treatment strategies in optic neuropathies, visual electrophysiology in humans, MRI

Rebecca Knickmeyer, PhD

Associate Professor, Pediatrics and Human Development
East Lansing Campus
 2114 Bioengineering Facility
 517-884-1876
 knickmey@msu.edu

Genetic and environmental influences on infant brain development, sexual differentiation of human brain, microbiome-gut-brain axis, neuroimaging

Arjun Krisnan, PhD

Assistant Professor, Computational Mathematics, Science, and Engineering
East Lansing Campus
 2507H Engineering
 517-432-0372
 arjun@msu.edu

Computational data-driven approaches for resolving, understanding, and tackling the heterogeneity of complex traits and diseases.

Geoffroy Laumet, PhD

Assistant Professor, Physiology
East Lansing Campus
 3184 Biomedical and Physical Sciences
 517-884-5057
 laumetge@msu.edu

Neurobiology of Chronic Pain

Gina M. Leinninger, PhD

Assistant Professor, Physiology
East Lansing Campus
 3183 Biomedical and Physical Sciences
 517-884-5123
 leinning@msu.edu

Central regulation of feeding and other motivated behaviors

Weiming Li, PhD

Professor, Fisheries and Wildlife, Physiology
East Lansing Campus
 100 Giltner Hall
 517-432-6705
 liweim@msu.edu

Pheromone regulation of behavior and neuroendocrine olfaction, functional genomics

Wen Li, PhD

Associate Professor, Electrical and Computer Engineering
East Lansing Campus
 1216 Engineering
 517-353-7832
 wenli@egr.msu.edu

MEMS/NEMS, neuroprosthetic devices, micro/nano sensors and actuators, nanoelectronics, and microsystem integration and packaging technologies.

Jack W. Lipton, PhD

Professor and Chair, Translational Neuroscience
Professor, Neurology & Ophthalmology
Grand Rapids Campus
 Grand Rapids Research Center
 616-234-0950
 jack.lipton@hc.msu.edu

Developmental exposure to drugs of abuse, development of the dopamine system, etiology and experimental therapeutics of Parkinson's disease

Taosheng Liu, PhD

Associate Professor, Psychology
East Lansing Campus
 289A Psychology
 517-432-6694
 tsliu@msu.edu

Visual perception and attention, attentional control, object recognition, neural mechanisms of perception and cognition

Joseph S. Lonstein, PhD

Professor, Psychology
East Lansing Campus
 219 Giltner Hall
 517-353-8675
 lonstein@msu.edu

Neural and hormonal control of peripartum anxiety disorders and postpartum maternal care

Keith J. Lookingland, PhD

Associate Professor, Pharmacology & Toxicology
East Lansing Campus
 B432 Life Science
 517-353-8971
 lookingl@msu.edu

Development of neuroprotective pharmacological agents and strategies for the treatment of dopamine neurodegenerative disorders including Parkinson's Disease and Restless Legs Syndrome (RLS)

Michelle S. Mazei-Robison, PhD

Associate Professor, Physiology
East Lansing Campus
 3182 Biomedical and Physical Sciences
 517-884-5004
 mazeirob@msu.edu

Drug- and stress-induced changes in behavior, neuronal signaling, and neuronal morphology

J. Devin McAuley, PhD

Professor, Psychology
East Lansing Campus
 282B Psychology
 517-353-9069
 dmcauley@msu.edu

Auditory perception, attention, and cognition, timing and rhythm, relationship between music and language processing, computational modeling, and neuroimaging

Dar Meshi, PhD

Assistant Professor, Advertising and Public Relations
East Lansing Campus
 324 Communication Arts and Sciences
 517-355-1282
 darmeshi@msu.edu

Neural processing of social information, social media use, decision making, social influence.

Kyle E. Miller, PhD

Associate Professor, Integrative Biology
East Lansing Campus
 336 Natural Science
 517-353-9283
 kmiller@msu.edu

Axonal elongation and organelle transport in neurons

Adam J. Moeser, PhD, DVM

Associate Professor and Matilda R. Wilson Endowed Chair, Large Animal Clinical Sciences, Department of Physiology
East Lansing Campus
 G326 Veterinary Medical Center
 517-353-5978
 moeserad@cvm.msu.edu

Pathophysiology of Stress-Induced Gastrointestinal and Immune Disorders

David G. Morgan, PhD

Professor, Translational Neuroscience
Grand Rapids Campus
 Grand Rapids Research Center
 616-234-2846
 morga294@msu.edu

Alzheimer’s disease, mouse models, amyloid, tau, microglia

Jason S. Moser, Ph.D.

Associate Professor, Psychology
East Lansing Campus
 110B Psychology
 517-355-2159
 jmoser@msu.edu

Cognitive and affective neuroscience approaches to the study of self-regulation and anxiety

Richard R. Neubig, MD, PhD

Professor and Chair, Pharmacology & Toxicology
East Lansing Campus
 B440 Life Science
 517-353-7145
 rneubig@msu.edu

G protein signaling in genetic epilepsies and movement disorders

Antonio A. Nunez, PhD

Associate Dean, Graduate School
Professor, Psychology

East Lansing Campus
 102 Giltner Hall
 517-353-9066
 nunez@msu.edu

Circadian and seasonal rhythms, neuroendocrinology

Galit Pelled, PhD

Professor, Biomedical Engineering and Department of Radiology
East Lansing Campus
 2114 Bioengineering Facility
 517-884-1876
 paneth@msu.edu

Neuromodulation, Neuroimaging of cortical function, Post-injury plasticity, Somatosensory system, Traumatic brain injury, Peripheral nerve injury, molecular probes, Optical imaging, Development of molecular-based neuromodulation technologies

Matthew B. Pontifex, PhD

Assistant Professor, Kinesiology
East Lansing Campus
 126E IM Sports Circle
 517-432-5105
 pontifex@msu.edu

ERP, behavioral, and neuropsychological investigations of the relation between physical health and cognition during maturation

Erin K. Purcell, PhD

Assistant Professor, Biomedical Engineering, Electrical And Computer Engineering
East Lansing Campus
 334A Engineering
 517-432-8137
 epurcell@msu.edu

Regenerate and redefine the interface between neurons and electrodes implanted in the brain, improving the understanding and control of device-tissue integration

Susan M. Ravizza, PhD

Associate Professor, Psychology
East Lansing Campus
 285C Psychology
 517-432-3366
 ravizzas@msu.edu

Cognitive processes necessary to achieve goals in a constantly changing environment

Mark Reimers, PhD

Associate Professor, Neuroscience Program
East Lansing Campus
 2117 Bioengineering Facility
 reimersm@msu.edu

A.J. Robison, PhD

Assistant Professor, Physiology
East Lansing Campus
 3180 Biomedical and Physical Sciences
 517-884-5003
 robiso45@msu.edu

How models of drug addiction and chronic stress alter gene expression in discreet brain regions, particularly the hippocampus

Debajit Saha, PhD

Assistant Professor, Biomedical Engineering
East Lansing Campus
 2115 Bioengineering Facility
 517-355-4169
 sahadeb3@msu.edu

Neural engineering and brain-computer interface (BCI)

Fathi M. Salem, PhD

Professor, Department of Electrical and Computer Engineering
East Lansing Campus
 2308D Engineering
 517-355-7695
 salemf@msu.edu

Modeling neuronal population synchrony and asynchrony and their relation to memory, processing, prediction, and control

Ralf Schmälzle, PhD

Assistant Professor, Communication
East Lansing Campus
 569 Communication Arts and Sciences
 517-355-6629
 schmaelz@msu.edu

Neuroimaging of dynamic media messages; Social, cognitive, and affective neuroscience; Message processing and audience response to messages

Erik M. Shapiro, PhD

Research Director, Radiology
Associate Professor, Physiology

East Lansing Campus
 184 Radiology
 517-884-3270
 shapir86@msu.edu

Molecular and cellular MRI, particularly in the use of MRI to track specific cell populations

Cheryl L. Sisk, PhD

University Distinguished Professor, Psychology
East Lansing Campus
 138 Giltner Hall
 517-355-5253
 sisk@msu.edu

Neuroendocrinology, neural development during puberty, steroid hormone regulation of neural development and behavior

Laura Smale, PhD

Professor, Integrative Biology, Psychology
East Lansing Campus
 222 Giltner Hall
 517-432-1632
 smale@msu.edu

Neural mechanisms controlling circadian rhythms in nocturnal and diurnal animals

Caryl E. Sortwell, PhD

Professor, Translational Neuroscience
Grand Rapids Campus
 Grand Rapids Research Center
 616-234-0959
 caryl.sortwell@hc.msu.edu

Primary neuronal cultures, ex vivo and in vivo gene therapy, stereotaxic surgery, immunohistochemistry, neuro substructure microdissections, behavioral evaluations of motor performance, microscopy, long term deep brain stimulation platform

Kathy Steece-Collier, PhD

Professor, Translational Neuroscience
Grand Rapids Campus
 Grand Rapids Research Center
 616-234-0969
 collie68@msu.edu

Brain plasticity in neurodegenerative disease models

Greg M. Swain, PhD

Professor, Chemistry
East Lansing Campus
 314 Chemistry
 517-355-9715 x229
 swain@chemistry.msu.edu

Application of electrochemical methods and sensors for studying the mechanisms and pharmacology of neuromuscular signaling in the vasculature and gastrointestinal tract

Laura L. Symonds, PhD

Undergraduate Director, Neuroscience Program
East Lansing Campus
 108 Giltner Hall
 517-432-2203
 symonds@msu.edu

Katy N Thakkar, PhD

Assistant Professor, Psychology
East Lansing Campus
 110C Psychology
 517-884-8489
 kthakkar@msu.edu

Cognitive and biological mechanisms of illness in schizophrenia

Barbara L. Thompson, PhD

Assistant Professor, Pediatrics and Human Development
Grand Lansing Campus
 Secchia Center
 616-234-2759
 barbara.thompson@hc.msu.edu

Social Play in Children with and without Autism Spectrum Disorder

Alexa H. Veenema, PhD

Associate Professor, Psychology
East Lansing Campus
 212 Giltner Hall
 517-303-1434
 aveenema@msu.edu

Neurobiology of social behavior

Irving E. Vega, PhD

Associate Professor, Translational Neuroscience
Grand Rapids Campus
 Grand Rapids Research Center
 616-234-2828
 irving.vega@hc.msu.edu

Adaptive proteome dynamics in neurodegenerative diseases

Daniel Vogt, PhD

Assistant Professor, Pediatrics and Human Development
Grand Rapids Campus
 Grand Rapids Research Center
 517-884-2843
 Daniel.vogt@hc.msu.edu

Development and maturation of GABAergic interneurons and their role in neurological disorders.

Hongbing Wang, PhD

Professor, Physiology
East Lansing Campus
 3179 Biomedical and Physical Sciences
 517-884-5119
 wangho@msu.edu

Neuronal intracellular signaling in neuroplasticity, brain function, and neurological disorders

Arthur J. Weber, PhD

Professor, Physiology
East Lansing Campus
 2198 Biomedical and Physical Sciences
 517-884-5041
 weberar@msu.edu

Structure-function relation of retinal ganglion cells undergoing glaucoma-related degeneration in the primate eye. Development of treatment strategies aimed at mitigating or preventing glaucomatous retinal ganglion cell degeneration

Juyang (John) Weng, PhD

Professor, Computer Science & Engineering
East Lansing Campus
 3144 Engineering
 517-353-4388
 weng@msu.edu

Computational modeling of nervous systems, mental architectures, neural networks, development, and learning

Michael R. Williams, PhD

Assistant Professor, Pediatrics and Human Development
Grand Rapids Campus
 Grand Rapids Research Center
 616-234-2845
 will3434@msu.edu

The role of Autism Spectrum Disorder (ASD) candidate genes in neuronal development

Lily Yan, MD, PhD

Associate Professor, Psychology
East Lansing Campus
 218 Giltner Hall
 517-432-8189
 yanl@msu.edu

Neural basis underlying the modulatory effects of ambient light on emotion and cognition.

David C. Zhu, PhD

Professor, Radiology, Psychology
Adjunct Professor, Electrical & Computer Engineering
East Lansing Campus
 124 Radiology Building
 517-884-3345
 David.Zhu@radiology.msu.edu

Magnetic Resonance Imaging (MRI) technique development. Use neuroimaging to understand mild traumatic brain injury, normal aging, Alzheimer's disease (AD), AD risk reduction, and effects of hypertension on the brain.