Neuroscience Program Seminar

Fall 2017 Seminar Schedule

 

Speaker

Michael Johnson

University of Kansas

Title

Unraveling the neurochemical mechanisms of chemobrain

Abstract

Chemotherapy-induced cognitive impairment (‘chemobrain’) is a syndrome in which deficits in executive function occur as a result of administration of cancer chemotherapy agents. In this seminar, findings obtained in two model organisms, rats and zebrafish, will be detailed. Rats treated with chemotherapeutic agents commonly used in humans have revealed deficits in fundamental components of executive function, including inhibition, working memory, and attentional shifting. Importantly, these deficits were also accompanied by specific functional neurochemical abnormalities, measured with fast-scan cyclic voltammetry (FSCV). Also described will be work in which we have developed methodology to measure sub-second neurotransmitter release events in intact zebrafish whole brain and have applied these techniques to measure the impact of chemotherapy exposure on neurotransmitter release and uptake.

 

Hosts

Dr. Greg Swain

Location

Thursday, October 19th, 2017 at 12:30pm

Room 1425 BPS

 

This seminar will originate from Room 1425 BPS

This seminar is also available for viewing in Secchia Center Room 220

 

 

Connect via zoom - https://msu.zoom.us/j/893113407

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