Neuroscience Program Seminar
University of California, Davis
Oxytocin receptors in extended amygdala induce social vigilance
The neuropeptide oxytocin (OT) is a key regulator of social and emotional behaviors and it has been proposed that OT increases the salience of both positive and negative social cues. A single dose of systemic oxytocin receptor antagonist (L-368,899) increased social approach in female California mice exposed to social defeat but decreased social approach in males naïve to defeat. Stressed females that received an infusion of L-368,899 in to the anteromedial BNST increased social approach and decreased social vigilance responses. Our results suggest that OTR activation in anteromedial BNST induces a vigilance response in which individuals avoid, yet attend to unfamiliar social contexts. These results suggest that OTR antagonists may have unappreciated therapeutic potential for modulating social anxiety.
Dr. Alexa Veenema
Thursday, February 22, 2018 at 12:30pm
This seminar will originate from room 1425 BPS, East Lansing
This seminar is also available for viewing in Grand Rapids, room 102 A& B Grand Rapids Research Center